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Seguin ( sih-GHEEN) is a city in and the county seat of Guadalupe County, Texas, United States. The population was 29,433 at the 2020 census, and according to 2023 census estimates, the city is estimated to have a population of 36,013. Seguin's economy is primarily supported by a regional hospital, as well as the Schertz-Seguin Local Government Corporation water-utility, that supplies the surrounding Greater San Antonio areas from nearby aquifers as far as Gonzales County.
