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Pearsall ( PEER-sawl) is a city in and the county seat of Frio County, Texas, United States. The population was 7,325 at the 2020 census, down from 9,146 at the 2010 census. Pearsall is located near the center of Frio County. Interstate 35 bypasses the city on the west side, with access from Exits 99, 101, and 104.
